Frontiers in Pharmacology

Original Research

Published on 02 May 2025

An in-depth exploration of the association between olanzapine, quetiapine and acute pancreatitis based on real-world datasets and network toxicology analysis

Shuang Wang
Liying Song
Yuanjie Sun
Haonan Zhou
Jia Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529416

126 views

Original Research

Published on 02 May 2025

Low-dose statins restore innate immune response in breast cancer cells via suppression of mutant p53

Zi Wang
Meina Shi
Beijia Liu
Xuening Zhang
Wanjun Lin
Yanchao Yang
Zifeng Huang
Dongfan Yang
Tong Chu
Dayuan Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1492305

107 views

Original Research

Published on 02 May 2025

Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

Peile Wang
Jingli Lu
Jing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578643

Original Research

Published on 02 May 2025

Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway

Na Yang
Meiduo Huayu
Shanshan Su
Bin Hou
Zhanting Yang
Xingmei Nan
Zhanqiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582677

209 views

Original Research

Published on 02 May 2025

Gen-miR-5 derived from Gentianella acuta inhibits PFKP to prevent fibroblast activation and alleviate myocardial fibrosis

Hongyao Ge
Zhenyu Du
Weizhe Liu
Letian Wang
Junyang Li
Gaoshan Yang
Aiying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578877

Original Research

Published on 02 May 2025

Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice

Rui Wang
Fan Yang
Ying Liu
Meiting Peng
Lu Yu
Qinhui Hou
Yuan Liu
Zhenshun Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1506518

118 views

Original Research

Published on 02 May 2025

Compatibility optimization of the traditional Chinese medicines ‘Eczema mixture’ based on back-propagation artificial neural network and non-dominated sorting genetic algorithm

Xin He
Zhijie Song
Yanqun Yang
Siqi Wu
Shuo Meng
Huanyu E
Hongfei Li
Guoyu Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593783

356 views

Original Research

Published on 02 May 2025

Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury

Lili Huang
Yinqi Chen
Hua Zhou
Huihui Chen
Xiping Wu
Zhuochao Wu
Zhoudi Liu
Zhiwei Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552717

Systematic Review

Published on 02 May 2025

Cost-effectiveness analyses of amivantamab plus lazertinib and lazertinib versus osimertinib in non-small cell lung cancer with EGFR mutations

Hui Zhang
Yueyun Li
Yuhang Liu
Haonan Li
Hong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527614

165 views

Original Research

Published on 02 May 2025

Population pharmacokinetic model of high-dose methotrexate in Chinese patients with intracranial germ cell tumors

Jiashu Zhao
Ruoyun Wu
Sitian Zhang
Qian Lu
Ruitao Wang
Yingjun He
Zhigang Zhao
Shenghui Mei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548203

Original Research

Published on 02 May 2025

Comprehensive analysis of adverse events associated with vortioxetine using the FDA adverse event reporting system

Liangxia Li
Qianqian Xu
Liangfang Pang
Yarui Liu
Yuanyuan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519865

Review

Published on 02 May 2025

1-Nitro-2-phenylethane: a promising phytoconstituent to modulate neuroinflammation and oxidative stress with repercussions on neurological and psychiatric disorders

Lucas Villar Pedrosa Silva Pantoja
Emily Christie Maia Fonseca
Fábio José Coelho Souza-Junior
Brenda Costa da Conceição
Sarah Viana Farias
Joyce Kelly R. da Silva
José Guilherme Soares Maia
Pedro Iuri Castro Silva
Jofre Jacob Silva Freitas
Rui Daniel Prediger

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552295

111 views

Clinical Trial

Published on 02 May 2025

Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson’s disease

Hayam Ali AlRasheed
Mostafa M. Bahaa
Thanaa A. Elmasry
Eman I. Elberri
Fedaa A. Kotkata
Ramy M. El Sabaa
Yasmine M. Elmorsi
Mostafa M. Kamel
Walaa A. Negm
Amir O. Hamouda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1497261

161 views

Review

Published on 02 May 2025

Traditional Chinese medicine for lupus nephritis: modulation of autoimmune pathogenesis

Zhiyan Huang
Xiaolong Li
Qingmiao Zhu
Mengyu Zhu
Yongsheng Fan
Ting Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523272

119 views

Review

Published on 02 May 2025

Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation

Jiani Li
LiQuan Zhou
ZuoWei Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583711

Original Research

Accepted on 01 May 2025

Establishment of a new approach for quality evaluation of Cremastrae Pseudobulbus Pleiones Pseudobulbus (Shancigu) based on multicomponent analysis and anti-liver cancer efficacy

Yuxin Cao
Zhuangzhuang Hao
Mengmeng Liu
Jingwen Xue
Yuqing Wang
Tingyue Jiang
Ge Zhang
Wenxin Fan
Chunguo Wang
Jinli Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544982